Abstract | BACKGROUND: METHODS: Anesthetized, open-chest rabbits were instrumented for production of myocardial ischemia (30 minutes) and subsequent reperfusion (120 minutes), after which myocardial infarct size was measured. Animals were treated intravenously with either saline solution, ramiprilat (50 micrograms/kg), the bradykinin2 receptor antagonist HOE 140 (1 microgram/kg), ramiprilat + HOE 140, angiotensin II (2.5 ng.kg-1.min-1), the angiotensin II receptor antagonist losartan (20 mg/kg), ramiprilat + angiotensin II, the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (100 micrograms.kg-1.min-1), or ramiprilat + NG-nitro-L-arginine methyl ester. RESULTS: CONCLUSIONS:
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Authors | J C Hartman |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 60
Issue 3
Pg. 789-92
(Sep 1995)
ISSN: 0003-4975 [Print] Netherlands |
PMID | 7545893
(Publication Type: Journal Article)
|
Chemical References |
- Adrenergic beta-Antagonists
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors
- Biphenyl Compounds
- Bradykinin Receptor Antagonists
- Imidazoles
- Receptors, Angiotensin
- Receptors, Bradykinin
- Tetrazoles
- Angiotensin II
- Nitric Oxide
- ramiprilat
- icatibant
- Arginine
- Nitric Oxide Synthase
- Amino Acid Oxidoreductases
- Losartan
- Ramipril
- Bradykinin
- NG-Nitroarginine Methyl Ester
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Topics |
- Adrenergic beta-Antagonists
(administration & dosage, therapeutic use)
- Amino Acid Oxidoreductases
(antagonists & inhibitors)
- Angiotensin II
(physiology)
- Angiotensin Receptor Antagonists
- Angiotensin-Converting Enzyme Inhibitors
(administration & dosage, therapeutic use)
- Animals
- Arginine
(administration & dosage, analogs & derivatives, therapeutic use)
- Biphenyl Compounds
(administration & dosage, therapeutic use)
- Bradykinin
(administration & dosage, analogs & derivatives, antagonists & inhibitors, physiology, therapeutic use)
- Bradykinin Receptor Antagonists
- Heart
(drug effects)
- Imidazoles
(administration & dosage, therapeutic use)
- Losartan
- Myocardial Infarction
(pathology, prevention & control)
- Myocardial Ischemia
(therapy)
- Myocardial Reperfusion
- Myocardial Reperfusion Injury
(prevention & control)
- NG-Nitroarginine Methyl Ester
- Nitric Oxide
(antagonists & inhibitors, physiology)
- Nitric Oxide Synthase
- Rabbits
- Ramipril
(administration & dosage, analogs & derivatives, therapeutic use)
- Receptors, Angiotensin
(drug effects)
- Receptors, Bradykinin
(drug effects)
- Tetrazoles
(administration & dosage, therapeutic use)
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