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Expression of human chorionic gonadotropin beta subunit genes in superficial and invasive bladder carcinomas.

Abstract
Increased serum levels of human chorionic gonadotropin beta subunit (hCG beta) were described previously in patients with bladder cancer. To obtain insight into such production of hCG beta, the expression of hCG beta 7, 8, 5, and 3 genes in bladder carcinomas and normal urothelia was investigated by reverse transcription PCR. Surprisingly, hCG beta mRNAs were detected in both normal urothelial and carcinomatous cells. However, tumor progression was characterized by different patterns of transcription of the hCG beta genes; the beta 7 gene was the only gene transcribed in normal urothelia and Ta tumors included in this study, whereas in addition to beta 7, genes beta 5, 8, and 3 were transcribed in T1 to T4 tumors. Moreover, transcription levels of the latter three genes increased with the stage of the disease. These observations showed that dramatic modifications in the expression of hCG beta genes accompany progression of bladder carcinomas.
AuthorsV Lazar, S G Diez, A Laurent, Y Giovangrandi, F Radvanyi, D Chopin, J M Bidart, D Bellet, M Vidaud
JournalCancer research (Cancer Res) Vol. 55 Issue 17 Pg. 3735-8 (Sep 01 1995) ISSN: 0008-5472 [Print] United States
PMID7543817 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Biomarkers, Tumor
  • Chorionic Gonadotropin
  • Chorionic Gonadotropin, beta Subunit, Human
  • Peptide Fragments
  • RNA, Messenger
  • RNA, Neoplasm
Topics
  • Base Sequence
  • Biomarkers, Tumor (analysis, genetics)
  • Chorionic Gonadotropin (analysis, genetics)
  • Chorionic Gonadotropin, beta Subunit, Human
  • Humans
  • Molecular Sequence Data
  • Peptide Fragments (analysis, genetics)
  • RNA, Messenger (analysis)
  • RNA, Neoplasm (analysis)
  • Urinary Bladder Neoplasms (genetics)

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