Long-term enhancement of dopamine release by high frequency tetanic stimulation via a N-methyl-D-aspartate-receptor-mediated pathway in rat striatum.

Abstract

We studied the effects of high frequency tetanic stimulation of the striatum on the KCl (20 mM)-evoked dopamine release in rat striatal slices. The KCl-evoked dopamine release was potentiated by high frequency tetanic stimulation (10-20 Hz) of the striatum including the corticostriatal fibers, and this potentiation was observed until 3 h after high frequency tetanic stimulation. Potentiation of dopamine release after high frequency tetanic stimulation was induced not only by KCl but also by glutamate in Mg(2+)-free medium, N-methyl-D-aspartate in Mg(2+)-free medium, and by DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid. 2-amino-5-phosphovalerate, 3-[(+/-)-2-carboxypiperazine-4-yl]-propyl-1-phosphonate or dibenzocycloheptaneimine, N-methyl-D-aspartate receptor inhibitors, abolished enhancement by tetanus, whereas, 6,7-dinitroquinoxaline-2,3-dione, an antagonist of DL-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid ionotropic receptors, or L-2-amino-4-phosphonobutyrate, an antagonist of glutamate metabotropic receptors, showed no effect. Moreover, pretreatment with glutamate or N-methyl-D-aspartate in the absence of Mg2+ also facilitated dopamine release evoked by KCl concentrations. When extracellular Ca2+ was removed from the medium during pretreatment, potentiation by glutamate disappeared. We conclude that activation of N-methyl-D-aspartate receptors on dopaminergic nerve terminals in the striatum produces the long-term changes in efficacy of the response to KCl or glutamatergic agents. That is, plastical phenomena could exist at presynaptic levels between glutamatergic neurons and dopaminergic neurons in striatum.

• Authors: M Ochi, H Inoue, S Koizumi, S Shibata, S Watanabe
• Journal: Neuroscience (Neuroscience) Vol. 66 Issue 1 Pg. 29-36 (May 1995) ISSN: 0306-4522 [Print] United States
• PMID: 7543663 (Publication Type: Journal Article)

Chemical References

• Excitatory Amino Acid Agonists
• Excitatory Amino Acid Antagonists
• Receptors, N-Methyl-D-Aspartate
• Glutamic Acid
• N-Methylaspartate
• Potassium Chloride
• alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
• Dopamine

Topics

• Animals
• Dopamine (metabolism)
• Electric Stimulation
• Excitatory Amino Acid Agonists (pharmacology)
• Excitatory Amino Acid Antagonists (pharmacology)
• Glutamic Acid (pharmacology)
• In Vitro Techniques
• Long-Term Potentiation (physiology)
• Male
• N-Methylaspartate (pharmacology)
• Neostriatum (metabolism, physiology)
• Nerve Endings (drug effects, metabolism, physiology)
• Potassium Chloride (pharmacology)
• Rats
• Rats, Wistar
• Receptors, N-Methyl-D-Aspartate (agonists, antagonists & inhibitors, metabolism)
• alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (pharmacology)