Salivary secretion and histopathological effects after single administration of the muscarinic agonist SNI-2011 in MRL/lpr mice.

Abstract

The salivary secretion and the histopathological effects after administration of a single dose of cis-2-methylspiro (1,3-oxathiolane-5,3') quinuclidine hydrochloride hemihydrate (SNI-2011) were monitored in adult, male and female MRL/lpr mice, C57BL/6J mice and ICR mice. SNI-2011 (1-10 mg/kg, i.p.), dose-dependently increased the secretion of saliva in MRL/lpr mice. The flow rate decreased gradually over the course of 60 min. The total volume of saliva, secreted in response to SNI-2011, was significantly higher in male than in female MRL/lpr mice, but there was no significant difference in this parameter between male and female C57BL/6J and ICR mice. Degeneration, apparent as atrophy and necrosis of serous cells in MRL/lpr mice, was reversed by treatment with SNI-2011 (3 and 6 mg/kg). These results suggest that SNI-2011 could be useful in the treatment of xerostomia in patients with Sjögren's syndrome.

• Authors: Y Iwabuchi, M Katagiri, T Masuhara
• Journal: Archives internationales de pharmacodynamie et de therapie (Arch Int Pharmacodyn Ther) 1994 Nov-Dec Vol. 328 Issue 3 Pg. 315-25 ISSN: 0003-9780 [Print] Belgium
• PMID: 7542865 (Publication Type: Journal Article)

Chemical References

• Parasympathomimetics
• Quinuclidines
• Thiophenes
• cevimeline

Topics

• Animals
• Autoimmune Diseases (physiopathology)
• Dose-Response Relationship, Drug
• Female
• Injections, Intraperitoneal
• Male
• Mice
• Mice, Inbred C57BL
• Mice, Inbred ICR
• Parasympathomimetics (administration & dosage, toxicity)
• Parotid Gland (drug effects, metabolism, pathology)
• Quinuclidines (administration & dosage, toxicity)
• Saliva (metabolism)
• Salivary Glands (drug effects, metabolism, pathology)
• Sex Factors
• Species Specificity
• Staining and Labeling
• Sublingual Gland (drug effects, metabolism, pathology)
• Submandibular Gland (drug effects, metabolism, pathology)
• Thiophenes