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The effect of platelet activating factor antagonist (BN 52021) on acute experimental pancreatitis with reference to multiorgan oxidative stress.

Abstract
Acute hemorrhagic pancreatitis was induced in Wistar rats using a retrograde intraductal injection of 5% Na-taurocholate. Rats were treated with platelet-activating factor receptor (PAF) antagonist--BN 52021 (5 mg/kg) and sacrificed at 1 and 3 h after induction of acute pancreatitis. Malondialdehyde and sulfhydryl groups concentration were measured in pancreatic, lung, and liver tissue as a parameter of oxidant-antioxidant balance. We have shown that BN 52021 exerts only partial protecting effect against Na-TC-induced AP in rats. The positive effects of BN 52021 were expressed by: (1) Significant reduction of hyperamylasemia accompanied by lower malondialdehyde accumulation in pancreatic tissue; (2) Prevention of sulflhydryl groups depletion in lung tissue; (3) Diminution of necrotic and inflammatory changes in pancreatic tissue; and (4) Improvement of survival rate. We suggest that these effects may depend on the inhibition of PAF-mediated activation and oxidant generation by phagocytes.
AuthorsA Dabrowski, A Gabryelewicz, L Chyczewski
JournalInternational journal of pancreatology : official journal of the International Association of Pancreatology (Int J Pancreatol) Vol. 17 Issue 2 Pg. 173-80 (Apr 1995) ISSN: 0169-4197 [Print] United States
PMID7542692 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Diterpenes
  • Ginkgolides
  • Lactones
  • Platelet Activating Factor
  • Sulfhydryl Compounds
  • Malondialdehyde
  • ginkgolide B
  • Amylases
Topics
  • Acute Disease
  • Amylases (blood)
  • Animals
  • Disease Models, Animal
  • Diterpenes
  • Ginkgolides
  • Lactones (pharmacology)
  • Liver (drug effects, metabolism)
  • Lung (drug effects, metabolism)
  • Male
  • Malondialdehyde (metabolism)
  • Organ Specificity
  • Oxidative Stress (drug effects)
  • Pancreas (drug effects, metabolism, pathology)
  • Pancreatitis (drug therapy, etiology, metabolism)
  • Platelet Activating Factor (antagonists & inhibitors)
  • Rats
  • Rats, Wistar
  • Sulfhydryl Compounds (metabolism)

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