Abstract |
Acute hemorrhagic pancreatitis was induced in Wistar rats using a retrograde intraductal injection of 5% Na- taurocholate. Rats were treated with platelet-activating factor receptor (PAF) antagonist-- BN 52021 (5 mg/kg) and sacrificed at 1 and 3 h after induction of acute pancreatitis. Malondialdehyde and sulfhydryl groups concentration were measured in pancreatic, lung, and liver tissue as a parameter of oxidant- antioxidant balance. We have shown that BN 52021 exerts only partial protecting effect against Na-TC-induced AP in rats. The positive effects of BN 52021 were expressed by: (1) Significant reduction of hyperamylasemia accompanied by lower malondialdehyde accumulation in pancreatic tissue; (2) Prevention of sulflhydryl groups depletion in lung tissue; (3) Diminution of necrotic and inflammatory changes in pancreatic tissue; and (4) Improvement of survival rate. We suggest that these effects may depend on the inhibition of PAF-mediated activation and oxidant generation by phagocytes.
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Authors | A Dabrowski, A Gabryelewicz, L Chyczewski |
Journal | International journal of pancreatology : official journal of the International Association of Pancreatology
(Int J Pancreatol)
Vol. 17
Issue 2
Pg. 173-80
(Apr 1995)
ISSN: 0169-4197 [Print] United States |
PMID | 7542692
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Diterpenes
- Ginkgolides
- Lactones
- Platelet Activating Factor
- Sulfhydryl Compounds
- Malondialdehyde
- ginkgolide B
- Amylases
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Topics |
- Acute Disease
- Amylases
(blood)
- Animals
- Disease Models, Animal
- Diterpenes
- Ginkgolides
- Lactones
(pharmacology)
- Liver
(drug effects, metabolism)
- Lung
(drug effects, metabolism)
- Male
- Malondialdehyde
(metabolism)
- Organ Specificity
- Oxidative Stress
(drug effects)
- Pancreas
(drug effects, metabolism, pathology)
- Pancreatitis
(drug therapy, etiology, metabolism)
- Platelet Activating Factor
(antagonists & inhibitors)
- Rats
- Rats, Wistar
- Sulfhydryl Compounds
(metabolism)
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