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Differential expression of apolipoprotein-D and prostate specific antigen in benign and malignant prostate tissues.

AbstractPURPOSE:
To investigate Apolipoprotein-D (Apo-D) and prostate specific antigen (PSA) immunohistochemical staining of nonmalignant and malignant human prostate tissues.
MATERIALS AND METHODS:
Apolipoprotein-D and PSA immunoreactivity were evaluated by video image analysis in nonmalignant prostates and in 30 stage D2 prostate cancers.
RESULTS:
Apolipoprotein-D was detected in all 30 tumors, and the level of staining was elevated in comparison to age-matched nonmalignant prostates (p < 0.05). In contrast, the level of PSA staining in tumors was less than that detected in nonmalignant prostates.
CONCLUSIONS:
Apolipoprotein-D is expressed in normal human prostate. Elevated Apo-D staining is associated with advanced prostate cancer.
AuthorsJ O Aspinall, J M Bentel, D J Horsfall, D E Haagensen, V R Marshall, W D Tilley
JournalThe Journal of urology (J Urol) Vol. 154 Issue 2 Pt 1 Pg. 622-8 (Aug 1995) ISSN: 0022-5347 [Print] United States
PMID7541868 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Apolipoproteins
  • Apolipoproteins D
  • Prostate-Specific Antigen
Topics
  • Adolescent
  • Adult
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Apolipoproteins (biosynthesis)
  • Apolipoproteins D
  • Child
  • Child, Preschool
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Prostate-Specific Antigen (biosynthesis)
  • Prostatic Diseases (metabolism)
  • Prostatic Neoplasms (metabolism)

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