[Combined effect of bleomycin and SDB-ethylenediamine, a synthetic isoprenoid, on oral squamous carcinoma cell lines and transplantable nude mouse tumors].

Abstract

Combined effect of bleomycin (BLM) and N-solanyl-N, N'-bis (3, 4-di-methoxy-benzyl)-ethylenediamine (SDB-ethylenediamine), a synthetic isoprenoid was studied on 3 oral squamous carcinoma cell lines (SCCTF, SCCKN, SCCRY) and clonal cell lines from SCCRY in vitro and on transplantable nude mouse tumors. The cytotoxicity of SDB-ethylenediamine varied among those cell lines in vitro. SDB-ethylenediamine potentiated more than 2-fold the cytotoxic effect of BLM in 6 cell lines, but no distinct correlation was found between cytotoxicity of SDB-ethylenediamine and potentiation by BLM. Compared with verapamil, the cytotoxic effect of BLM was potentiated 3.9-fold by SDB-ethylenediamine in SCCTF. The growth of the transplantable nude mouse tumors (SCCRY and SCCTF) was strongly suppressed when BLM was combined with SDB-ethylenediamine. Correlation between BLM resistance and potentiation of BLM by SDB-ethylenediamine was not observed in this experiment.

• Authors: Y Takahashi, M Urade, H Kishimoto, T Arimoto, T Yanagisawa, W Yoshioka
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 22 Issue 7 Pg. 883-7 (Jun 1995) ISSN: 0385-0684 [Print] Japan
• PMID: 7540824 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Ethylenediamines
• Terpenes
• N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl)ethylenediamine
• Bleomycin

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Bleomycin (pharmacology)
• Carcinoma, Squamous Cell (pathology)
• Drug Resistance
• Drug Synergism
• Ethylenediamines (pharmacology)
• Humans
• Male
• Mice
• Mice, Nude
• Mouth Neoplasms (pathology)
• Neoplasm Transplantation
• Terpenes (pharmacology)
• Tumor Cells, Cultured (drug effects)