Abstract | BACKGROUND/AIMS: METHODS: RESULTS: Compared to normal animals, rats with cirrhosis had significantly higher D40 values for angiotensin II (171 +/- 57 vs. 344 +/- 41 ng/kg), phenylephrine (2.6 +/- 0.2 vs. 26.4 +/- 10.7 micrograms/kg) and vasopressin (73 +/- 19 vs. 401 +/- 150 mU/kg). Pressor responses to Bay K 8644 did not differ between normal rats and rats with cirrhosis (8.8 +/- 0.9 vs. 10.5 +/- 2.1 micrograms/kg). CONCLUSIONS:
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Authors | M Hartleb, R Moreau, C Gaudin, D Lebrec |
Journal | Journal of hepatology
(J Hepatol)
Vol. 22
Issue 2
Pg. 202-7
(Feb 1995)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 7540637
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Calcium Channels
- Ganglionic Blockers
- Vasopressins
- Angiotensin II
- Phenylephrine
- 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
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Topics |
- 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
(pharmacology)
- Angiotensin II
(pharmacology)
- Animals
- Blood Vessels
(drug effects)
- Calcium Channels
(drug effects, metabolism)
- Dose-Response Relationship, Drug
- Ganglionic Blockers
(pharmacology)
- Liver Cirrhosis, Experimental
(physiopathology)
- Male
- Phenylephrine
(pharmacology)
- Rats
- Rats, Sprague-Dawley
- Vasopressins
(pharmacology)
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