[Low titer cold agglutinin disease due to anti-HI antibody and a review of this disease in Japan].

A 79 year-old Japanese man was admitted because of brownish urine and Raynaud phenomenon. Laboratory data showed mild anemia with reticulocytosis, positive direct Coombs test against anti-C3, elevated level of lactate dehydrogenase, undetectable level of serum haptoglobin and low titer of cold agglutinin (1:256 at 4 degrees C), the immunoglobulin subclass of which was IgM. Cold agglutinin disease is usually associated with very high levels of cold agglutinins, the specificity of which is anti-I. This case had low titer cold agglutinin disease due to anti-HI cold agglutinin.
AuthorsH Yamauchi, K Iwamasa, K Yanagisawa, T Tamai, M Yasukawa, S Fujita
Journal[Rinshò„ ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 36 Issue 4 Pg. 334-8 (Apr 1995) ISSN: 0485-1439 [Print] JAPAN
PMID7540224 (Publication Type: Case Reports, English Abstract, Journal Article, Review)
Chemical References
  • Agglutinins
  • Autoantibodies
  • Cryoglobulins
  • Epitopes
  • Hemagglutinins
  • cold agglutinins
  • Adolescent
  • Adult
  • Aged
  • Agglutinins (analysis)
  • Anemia, Hemolytic, Autoimmune (immunology)
  • Autoantibodies (analysis)
  • Cold Temperature
  • Cryoglobulins
  • Epitopes
  • Female
  • Hemagglutinins (analysis)
  • Humans
  • Male
  • Middle Aged

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