[Low titer cold agglutinin disease due to anti-HI antibody and a review of this disease in Japan].

Abstract

A 79 year-old Japanese man was admitted because of brownish urine and Raynaud phenomenon. Laboratory data showed mild anemia with reticulocytosis, positive direct Coombs test against anti-C3, elevated level of lactate dehydrogenase, undetectable level of serum haptoglobin and low titer of cold agglutinin (1:256 at 4 degrees C), the immunoglobulin subclass of which was IgM. Cold agglutinin disease is usually associated with very high levels of cold agglutinins, the specificity of which is anti-I. This case had low titer cold agglutinin disease due to anti-HI cold agglutinin.

• Authors: H Yamauchi, K Iwamasa, K Yanagisawa, T Tamai, M Yasukawa, S Fujita
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 36 Issue 4 Pg. 334-8 (Apr 1995) ISSN: 0485-1439 [Print] Japan
• PMID: 7540224 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Agglutinins
• Autoantibodies
• Cryoglobulins
• Epitopes
• Hemagglutinins
• cold agglutinins

Topics

• Adolescent
• Adult
• Aged
• Agglutinins (analysis)
• Anemia, Hemolytic, Autoimmune (immunology)
• Autoantibodies (analysis)
• Cold Temperature
• Cryoglobulins
• Epitopes
• Female
• Hemagglutinins (analysis)
• Humans
• Male
• Middle Aged