HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Protective effects of endothelin-1 on acute pancreatitis in rats.

Abstract
Endothelin-1, a 21-residue peptide isolated from vascular endothelial cells, has a broad spectrum of actions. To clarify the involvement of endothelin-1 in acute pancreatitis, we examined the effects of endothelin-1 and its receptor antagonist BQ-123 on cerulein-induced pancreatitis in rats. Rats were infused intravenously with heparin-saline (control), endothelin-1 (100 pmol/kg/hr), cerulein (5 micrograms/kg/hr), or cerulein plus endothelin-1 for 3.5 hr. In another experiment, cerulein or cerulein plus BQ-123 (3 mg/kg/hr) was infused. Infusion of cerulein caused hyperamylasemia and pancreatic edema. Endothelin-1, when infused with cerulein, decreased the extent of pancreatic edema with a significant increase in the pancreatic dry- to wet-weight ratio. Histological changes induced by cerulein were markedly attenuated when endothelin-1 was given with cerulein. In contrast, endothelin-receptor blockade with BQ-123 further augmented pancreatic edema caused by cerulein. The extent of inflammatory cell infiltration was greater than BQ-123 was given with cerulein. Endothelin-1 or BQ-123 had no influence on hyperamylasemia. This study suggests that endothelin-1 has protective effects on experimental acute pancreatitis.
AuthorsM Kogire, K Inoue, S Higashide, K Takaori, Y Echigo, Y J Gu, S Sumi, K Uchida, M Imamura
JournalDigestive diseases and sciences (Dig Dis Sci) Vol. 40 Issue 6 Pg. 1207-12 (Jun 1995) ISSN: 0163-2116 [Print] United States
PMID7540127 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Endothelin Receptor Antagonists
  • Endothelins
  • Peptides, Cyclic
  • Ceruletide
  • Amylases
  • cyclo(Trp-Asp-Pro-Val-Leu)
Topics
  • Acute Disease
  • Amylases (blood, drug effects)
  • Analysis of Variance
  • Animals
  • Ceruletide
  • Disease Models, Animal
  • Drug Evaluation, Preclinical
  • Endothelin Receptor Antagonists
  • Endothelins (blood, therapeutic use)
  • Male
  • Pancreas (drug effects, pathology)
  • Pancreatitis (blood, chemically induced, drug therapy, pathology)
  • Peptides, Cyclic (therapeutic use)
  • Rats
  • Rats, Wistar

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: