Inhibition of skin carcinogenesis in vivo by caffeine and other agents.

Abstract

The induction of skin cancer in mice of the Swiss (Carshalton) strain, by repeated irradiation with UV-light, was strikingly reduced by the local application of caffeine prior to each exposure. Theophylline displayed the same activity. These two substances have been selected as probable inhibitors of error-prone, postreplicative DNA repair. Conversely, reductone and chloroquine, which are considered as inhibitors of the error-free, prereplicative excision repair, did not modify the incidence of the tumors. Special emphasis has been given to the histologic behavior of radiolabeled caffeine in the normal and UV-irradiated epidermis of the mouse in vivo and to the ability of mouse epidermal cells in vitro to repair DNA after UV irradiation.

• Authors: F Zajdela, R Latarjet
• Journal: National Cancer Institute monograph (Natl Cancer Inst Monogr) Issue 50 Pg. 133-40 (Dec 1978) ISSN: 0083-1921 [Print] United States
• PMID: 753971 (Publication Type: Journal Article)

Chemical References

• Caffeine
• Malondialdehyde
• Chloroquine
• DNA
• Theophylline

Topics

• Animals
• Caffeine (metabolism, pharmacology)
• Cell Line
• Chloroquine (pharmacology)
• DNA (biosynthesis)
• DNA Repair (drug effects, radiation effects)
• Female
• Malondialdehyde (analogs & derivatives, pharmacology)
• Mice
• Neoplasms, Experimental (prevention & control)
• Neoplasms, Radiation-Induced (prevention & control)
• Skin (metabolism)
• Skin Neoplasms (etiology, prevention & control)
• Theophylline (pharmacology)
• Ultraviolet Rays (adverse effects)