[Doppler ultrasound studies in placental insufficiency as an indication of the effectiveness of hemodilution therapy].

Abstract

Early diagnosis of intrauterine growth retardation is important to ensure optimal obstetric monitoring. Current methods of diagnosing and assessing the growth retardation include clinical evaluation, various ultrasonic parameters and Doppler ultrasound. In this study Dopplersonographic measurements of the umbilical artery, fetal aorta and the middle cerebral artery were performed on 19 patients having been diagnosed with a placental insufficiency and maternal haemoconcentration. The patients were treated 10 days by a daily hypervolemic haemodilution with 500 ml 10% hydroxyethylstarch and 1000 ml ringersolution. The blood flow velocimetry showed changes in the fetal circulation characterized by a redistribution of the fetal blood flow. The aortic and umbilical resistance indices decreased. The resistance index of the middle cerebral artery demonstrated a significant rise during the haemodilution. The fetal circulatory changes represents a better oxygenation during the therapy with hydroxyethylstarch. The intravenous haemodilution can be seen as an effective and easy treatment of fetal growth retardation by increasing the placenta perfusion.

• Authors: L Molendijk, I Malburg, P Kopecky
• Journal: Zeitschrift fur Geburtshilfe und Neonatologie (Z Geburtshilfe Neonatol) 1995 Jan-Feb Vol. 199 Issue 1 Pg. 18-22 ISSN: 0948-2393 [Print] Germany
• Vernacular Title: Dopplersonographische Untersuchungen bei Plazentainsuffizienz als Hinweis auf die Effektivität der Hämodilutionstherapie.
• PMID: 7536998 (Publication Type: Journal Article)

Chemical References

• Hydroxyethyl Starch Derivatives

Topics

• Blood Flow Velocity (physiology)
• Female
• Fetal Growth Retardation (diagnostic imaging, physiopathology, therapy)
• Hemodilution
• Humans
• Hydroxyethyl Starch Derivatives (administration & dosage)
• Infant, Newborn
• Maternal-Fetal Exchange (physiology)
• Placenta (blood supply)
• Placental Insufficiency (diagnostic imaging, physiopathology, therapy)
• Pregnancy
• Prospective Studies
• Regional Blood Flow (physiology)
• Ultrasonography, Doppler
• Ultrasonography, Prenatal
• Umbilical Arteries (diagnostic imaging, physiopathology)
• Vascular Resistance (physiology)