Abstract |
We report a patient with refractory anemia with excess blasts who showed a lineage-unrestricted hematologic response to granulocyte colony-stimulating factor ( G-CSF). After 17 months of a stable disease state, the patient developed pneumonia, progression of cytopenia, and reduced cellularity and blast mass in the bone marrow. He was given G-CSF to overcome the pneumonia. Not only the neutrophil count, but also the platelet count increased soon after initiation of the G-CSF therapy; both counts became normal on the fifth day of the G-CSF therapy. Additionally, the anemia improved gradually. The neutrophil and platelet counts were maintained in the normal range for 3 months after cessation of the G-CSF. In vitro studies showed that G-CSF alone stimulated megakaryocyte colony formation from bone marrow mononuclear cells (BMMNC), and accessory cells in the BMMNC were necessary for expression of this G-CSF-induced in vitro megakaryocytopoiesis. These results suggest that, in coordination with accessory cells, G-CSF stimulated megakaryocytopoiesis in the patient. This case provides valuable information for understanding the mechanisms of a lineage-unrestricted hematologic response to G-CSF, which is very rarely observed in MDS.
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Authors | N Yokose, K Ogata, E An, H Tamura, K Kamikubo, K Dan, T Nomura |
Journal | Annals of hematology
(Ann Hematol)
Vol. 70
Issue 3
Pg. 163-7
(Mar 1995)
ISSN: 0939-5555 [Print] Germany |
PMID | 7536478
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Granulocyte Colony-Stimulating Factor
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Topics |
- Anemia, Refractory, with Excess of Blasts
(drug therapy)
- Bone Marrow
(drug effects)
- Bone Marrow Cells
- Granulocyte Colony-Stimulating Factor
(therapeutic use)
- Hematopoiesis
(drug effects)
- Humans
- Male
- Megakaryocytes
(cytology)
- Middle Aged
- Monocytes
(cytology, drug effects)
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