Abstract | OBJECTIVE: DESIGN: Prospective study. PATIENTS: RESULTS:
Cyfra 21-1 concentration was elevated in 60% of the new patients with squamous cell carcinoma but only in 8% of patients with benign tumors and 3.5% of the healthy controls. At a cutoff of 1.3 ng/mL, the sensitivity of the test was 60%, the specificity was 94%, positive predictive value was 75%, and negative predictive value was 89%. The marker levels tended to follow the clinical course of the disease and were useful for therapy monitoring. Cyfra 21-1 levels were in good correlation with the tumor stage expressed by the local (T) and the lymphatic spread (N) and were inversely correlated with histologic grade, eg, higher in poorly differentiated carcinoma than in well-differentiated squamous cell carcinoma. CONCLUSION:
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Authors | I Doweck, M Barak, E Greenberg, N Uri, J Kellner, M Lurie, N Gruener |
Journal | Archives of otolaryngology--head & neck surgery
(Arch Otolaryngol Head Neck Surg)
Vol. 121
Issue 2
Pg. 177-81
(Feb 1995)
ISSN: 0886-4470 [Print] United States |
PMID | 7530966
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- Keratins
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(blood)
- Carcinoma, Squamous Cell
(diagnosis)
- Female
- Head and Neck Neoplasms
(diagnosis)
- Humans
- Keratins
(blood)
- Male
- Middle Aged
- Predictive Value of Tests
- Prospective Studies
- Sensitivity and Specificity
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