[CHOP-Bleo therapy in high-malignancy non-Hodgkin lymphoma].

Abstract

The records of 85 patients were reviewed in order to study the efficacy of CHOP-Bleo combination chemotherapy and to determine factors influencing prognosis. The patients were treated between 1978 and 1989, the median age was 44.4 (range, 15-68) years, the majority of them were in advanced clinical stages (92.9%). Systemic (B) symptoms were present in half of the patients and a quarter of them had bulky disease. Complete response was achieved in 36 patients (42.5%), partial response in 26 patients (30.5%), and primary treatment failure occurred in 23 patients (27.0%). The median survival was 92.6 months and 36.5% of the patients remained relapse-free at 10 years. The expected 5-year and 10-year survival rates were 47% and 39%, respectively. Using multivariate analysis B symptoms, involvation of two or more extralymphatic sites and lymphoblastic histologic subtype proved to be unfavourable prognostic factors. The most frequently observed side-effects were myelosuppression, neurotoxicity and gastrointestinal symptoms. No treatment-related death have occurred.

• Authors: T Schneider, Z Molnár, E Várady, G Ringwald, T Fleischmann
• Journal: Orvosi hetilap (Orv Hetil) Vol. 135 Issue 50 Pg. 2759-63 (Dec 11 1994) ISSN: 0030-6002 [Print] Hungary
• Vernacular Title: Kifejezett malignităsú non-Hodgkin lymphomás betegek CHOP-Bleo kezelése.
• PMID: 7530823 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Bleomycin
• Vincristine
• Doxorubicin
• Cyclophosphamide
• Prednisone

Topics

• Adolescent
• Adult
• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bleomycin (administration & dosage, adverse effects, therapeutic use)
• Cyclophosphamide (administration & dosage, adverse effects, therapeutic use)
• Dose-Response Relationship, Drug
• Doxorubicin (administration & dosage, adverse effects, therapeutic use)
• Female
• Humans
• Immunophenotyping
• Lymphoma, Non-Hodgkin (classification, drug therapy, pathology)
• Male
• Middle Aged
• Multivariate Analysis
• Neoplasm Staging
• Prednisone (administration & dosage, adverse effects, therapeutic use)
• Prognosis
• Remission Induction
• Vincristine (administration & dosage, adverse effects, therapeutic use)