Abstract |
We retrospectively studied the factors affecting the rate of hematopoietic reconstitution (HR) in 118 patients with hematological malignancies who underwent peripheral blood progenitor cell (PBPC) transplantation at a single institution. The patients received a median number of 6.6 x 10(8) nucleated cells/kg corresponding to 9.5 x 10(4) (0.5-578) CFU-GM/kg and 6.8 x 10(6) (0.2-161) CD34-positive cells/kg. The median number of days to reach 500 polymorphonuclear cells/mm3 and 50,000 platelets/mm3 was 12.5 (6-93) and 14.5 (6-440) days, respectively. No patient died from infection during the aplastic phase. By multivariate analysis, we found that the dose of CFU-GM infused was the only factor that significantly affects the HR rate (p < 0.0001). Moreover, patients with acute myelogenous leukemia or those transplanted after busulfan or total-body irradiation conditioning regimens had a slower engraftment (p < 0.08). These results could lead to identifying patients who need growth factors posttransplantation and/or the reinfusion of "back-up" marrow together with PBPC.
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Authors | J Reiffers, C Faberes, J M Boiron, G Marit, C Foures, A M Ferrer, P Cony-Makhoul, M Puntous, P Bernard, G Vezon |
Journal | Journal of hematotherapy
(J Hematother)
Vol. 3
Issue 3
Pg. 185-91
( 1994)
ISSN: 1061-6128 [Print] United States |
PMID | 7530133
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD
- Antigens, CD34
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Topics |
- Actuarial Analysis
- Adolescent
- Adult
- Aged
- Antigens, CD
- Antigens, CD34
- Child
- Colony-Forming Units Assay
- Female
- Graft Survival
- Hematopoietic Stem Cell Transplantation
- Humans
- Leukemia
(mortality, therapy)
- Lymphoma
(mortality, therapy)
- Male
- Middle Aged
- Multiple Myeloma
(mortality, therapy)
- Platelet Count
- Retrospective Studies
- Survival Rate
- Time Factors
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