HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Type III procollagen N-terminal peptide and type IV collagen-7S level in the serum and BALF of patients with non-Hodgkin's lymphoma before and after chemotherapy].

Abstract
Combination chemotherapy regimens using multiple agents have been reported to produce long term survival in patients with non-Hodgkin's lymphoma (NHL). However, the adverse effects of those regimens, particularly pulmonary complications, have resulted in fatalities. We measured P-III-P and type IV collagen-7S level in the serum and BALF of 23 previously untreated NHL patients who underwent COP-BLAM III chemotherapy in which a high dose of bleomycin (BLM) was used, and studied the relationship between those parameters and the pulmonary functions in those patients. The parameters and pulmonary function were measured before the first course and after the completion of the fourth course of chemotherapy. As for pulmonary function, chemotherapy produced an increment of %DLCO value but no change in PaO2, %VC, and %FEV1.0. While serum P-III-P levels remained unchanged, P-III-P levels in BALF slightly decreased after the chemotherapy. Type IV collagen-7S levels both in serum and BALF showed no change after the chemotherapy. Serum P-III-P levels after the chemotherapy were significantly correlated with both total cell counts and lymphocyte counts in the BALF. But there was no correlation between serum P-III-P levels and %DLCO. Mild and early-Stage fibrosis was observed in the lungs of the patients who were treated with COP-BLAM III. Pulmonary adverse effects are not likely to be associated with the total administered dose of BLM, but are associated with individual susceptibility to BLM toxicity. Our results suggest that the chemotherapy should be discontinued or the dose of BLM should be reduced if the P-III-P level in BALF increases.
AuthorsN Niitsu, M Umeda
Journal[Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 35 Issue 11 Pg. 1267-75 (Nov 1994) ISSN: 0485-1439 [Print] Japan
PMID7529840 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Peptide Fragments
  • Procollagen
  • procollagen Type III-N-terminal peptide
  • Bleomycin
  • Procarbazine
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Collagen
  • Prednisone
Topics
  • Adolescent
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects)
  • Bleomycin (adverse effects)
  • Bronchoalveolar Lavage Fluid (chemistry)
  • Collagen (analysis, blood)
  • Cyclophosphamide (adverse effects)
  • Doxorubicin (adverse effects)
  • Female
  • Humans
  • Lymphoma, Non-Hodgkin (drug therapy, metabolism)
  • Male
  • Middle Aged
  • Peptide Fragments (analysis, blood)
  • Prednisone (adverse effects)
  • Procarbazine (adverse effects)
  • Procollagen (analysis, blood)
  • Pulmonary Fibrosis (chemically induced, metabolism)
  • Vincristine (adverse effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: