Thalifaberidine, a cytotoxic aporphine-benzylisoquinoline alkaloid from Thalictrum faberi.

Abstract

From Thalictrum faberi, thalifaberidine [1], a new aporphine-benzylisoquinoline alkaloid, together with four known alkaloids, thalifaramine [2], thalifaricine [3], thalifarazine [4], and thalifaronine [5], were isolated. Thalifaberidine [1] was identified as 6',8-desmethylthalifaberine, and its 1H- and 13C-nmr data were completely assigned through the use of one- and two-dimensional nmr techniques. Thalifaberidine [1], thalifaberine [6], and thalifasine [7] showed cytotoxic activity against several human cancer cell lines, as well as antimalarial activity.

• Authors: L Z Lin, S F Hu, K Zaw, C K Angerhofer, H Chai, J M Pezzuto, G A Cordell, J Lin, D M Zheng
• Journal: Journal of natural products (J Nat Prod) Vol. 57 Issue 10 Pg. 1430-6 (Oct 1994) ISSN: 0163-3864 [Print] United States
• PMID: 7528786 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Alkaloids
• Antimalarials
• Antineoplastic Agents, Phytogenic
• Aporphines
• Drugs, Chinese Herbal
• Reverse Transcriptase Inhibitors
• thalifaberidine

Topics

• Alkaloids (isolation & purification, pharmacology)
• Animals
• Antimalarials (isolation & purification, pharmacology)
• Antineoplastic Agents, Phytogenic (isolation & purification, pharmacology)
• Aporphines (chemistry, isolation & purification)
• Drugs, Chinese Herbal (isolation & purification, pharmacology)
• HIV (enzymology)
• Humans
• Magnetic Resonance Spectroscopy
• Medicine, Chinese Traditional
• Mice
• Reverse Transcriptase Inhibitors
• Tumor Cells, Cultured