HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Thromboxane receptor antagonist BMS-180291, but not aspirin, reduces the severity of pacing-induced ischemia in dogs.

Abstract
We determined the effect of thromboxane A2 (TXA2) prostaglandin endoperoxide (TP) receptor antagonism, using BMS-180291 or aspirin, on the severity of pacing-induced ischemia in anesthetized dogs. Thromboxane receptor antagonists may not only have antithrombotic activity, but may also have direct cardioprotective effects, unlike aspirin. Left anterior descending coronary artery (LAD) stenosis was adjusted so that a significant (10-12 mV) ST segment elevation was observed only when superimposed on atrial pacing. Each heart was subjected to 5-min episodes of pacing-induced ischemia 10, 40, and 70 min after initiation of BMS-180291 (1 mg/kg + 1 mg/kg/h) or vehicle. In the vehicle group, ST segment elevation was reproducible at all pacing-induced ischemia episodes, whereas BMS-180291 significantly reduced it by 30% at the later ischemia episodes. This reduction in ST segment increase was not accompanied by alterations in regional myocardial blood flow (RMBF) nor in hemodynamic status. Aspirin in the same model [10 mg/kg intravenously (i.v.) given 10 min before pacing-induced ischemia] did not significantly reduce ST segment elevation, indicating a lack of protective effect in this model. Thromboxane receptor blockade appears to protect myocardium subjected to pacing-induced ischemia, an effect not produced by aspirin.
AuthorsG J Grover, W A Schumacher, M L Ogletree
JournalJournal of cardiovascular pharmacology (J Cardiovasc Pharmacol) Vol. 24 Issue 3 Pg. 493-9 (Sep 1994) ISSN: 0160-2446 [Print] United States
PMID7528306 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Bridged Bicyclo Compounds, Heterocyclic
  • Oxazoles
  • Propionates
  • Receptors, Thromboxane
  • ifetroban
  • Aspirin
Topics
  • Angina Pectoris (drug therapy)
  • Animals
  • Aspirin (administration & dosage, pharmacology, therapeutic use)
  • Bridged Bicyclo Compounds, Heterocyclic
  • Cardiac Pacing, Artificial
  • Coronary Circulation (drug effects)
  • Disease Models, Animal
  • Dogs
  • Female
  • Hemodynamics (drug effects)
  • Injections, Intravenous
  • Male
  • Myocardial Ischemia (drug therapy)
  • Oxazoles (administration & dosage, blood, pharmacology, therapeutic use)
  • Propionates (administration & dosage, blood, pharmacology, therapeutic use)
  • Radioligand Assay
  • Receptors, Thromboxane (antagonists & inhibitors)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: