[Non-arteritic anterior ischemic optic neuropathy: long-term results after hemodilution therapy].

Abstract

BACKGROUND:

In patients with nonarteritic anterior ischemic optic neuropathy (AION) we investigated the long-term effect of hemodilution on functional results, recurrence rate in the affected and involvement of the second eye.

PATIENTS AND METHODS:

In a retrospective study we reviewed 24 patients ranging in age from 62 to 92 years (mean 77 years) with AION. The duration of follow-up was between 8-51 months (mean 24.8 months). All patients received iso- (Hct > 40%) or hypervolemic (Hct < or = 40%) hemodilution over 8-10 days with daily infusion of 10% hydroxyethyl-starch 200/0.5. The hematocrit decreased significant (p < 0.001) from 43.4 +/- 3.8% to 37.8 +/- 3.5% after this 10-day hemodilution treatment.

RESULTS:

After the longterm follow-up 29.1% of the patients had an improvement of the central vision by two or more lines, 16.7% had a deterioration, 54.2% remained unchanged. The resulting visual acuity was between 0.5-1.0 in 37.5%, between 0.4-0.1 in 41.7% and worse than 0.1 in 20.8%. Neither visual fields nor the VECP were significant changed by hemodilution. After the mean follow-up period of 24.8 months no recurrence occurred in the affected eye and the second eye as never involved.

CONCLUSION:

Hemodilution therapy has no significant longterm effect on visual acuity and visual fields, but it seems to have a beneficial influence on the recurrence rate in the affected and on the involvement of the second eye.

• Authors: A Haas, I Uyguner, G E Sochor, O Schmut, B Vidic, J Faulborn
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 205 Issue 3 Pg. 143-6 (Sep 1994) ISSN: 0023-2165 [Print] Germany
• Vernacular Title: Nichtarteriitische vordere ischämische Optikusneuropathie: Langzeitergebnisse nach Hämodilutionstherapie.
• PMID: 7527879 (Publication Type: English Abstract, Journal Article)

Chemical References

• Hydroxyethyl Starch Derivatives

Topics

• Aged
• Aged, 80 and over
• Evoked Potentials, Visual (drug effects)
• Female
• Follow-Up Studies
• Hematocrit
• Hemodilution (methods)
• Humans
• Hydroxyethyl Starch Derivatives (administration & dosage)
• Ischemia (blood, etiology, therapy)
• Long-Term Care
• Male
• Middle Aged
• Optic Nerve (blood supply)
• Optic Neuritis (blood, etiology, therapy)
• Recurrence
• Retrospective Studies
• Visual Acuity (drug effects)
• Visual Fields (drug effects)