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[Animal experiment evaluation of myocardial protection with a magnesium-asparaginate-procaine solution].

Abstract
Cardioplegic myocardial protection with magnesium asparaginate procaine (Cardioplegin) is assessed in normothermic ischemia by left ventricular function curves. Different ischemic times (20, 30, 40, and 50 min) and different doses of Cardioplegin (2, 4, and 6 ml/kg) were studied in 68 mongrel dogs. Postischemic myocardial function was depressed in all experiments. However, in the Cardioplegin groups all animals showed signs of recovery and a significant, but not dose-related, hemodynamic improvement compared to the controls.
AuthorsB Walpoth, M Fornaro, W von Gossler, M Turina
JournalChirurgisches Forum fur experimentelle und klinische Forschung (Chir Forum Exp Klin Forsch) Issue 1978 Pg. 99-102 ( 1978) ISSN: 0303-6227 [Print] Germany
Vernacular TitleTierexperimentelle Beurteilung des Myokardschutzes mittels Magnesium-asparaginat-procain-Lösung.
PMID752612 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Drug Combinations
  • Procaine
  • Sorbitol
  • Asparagine
Topics
  • Animals
  • Asparagine (administration & dosage, pharmacology)
  • Dogs
  • Drug Combinations
  • Heart (drug effects)
  • Heart Arrest, Induced
  • Ischemia (prevention & control)
  • Procaine (administration & dosage, pharmacology)
  • Sorbitol (administration & dosage, pharmacology)
  • Time Factors

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