Induction of cell surface interleukin 2 receptor alpha chain expression on non-T lymphoid leukemia cells.

Abstract

We examined nine cases of adult non-T lymphoid leukemia to investigate the cell surface inducibility of interleukin 2 receptor alpha chain (IL-2R alpha) and beta chain (IL-2R beta) after in vitro culture with and without recombinant human interleukin-1 beta (rhIL-1 beta). Induction of IL-2R alpha was observed in four of six cases with precursor B-cell acute lymphoblastic leukemia (pre-B ALL) and in all of three cases with B-cell mature lymphoid neoplasm (two chronic lymphocytic leukemia and one leukemic phase of non-Hodgkin's lymphoma). All of the IL-2R alpha-inducible cases could express this spontaneously even without rhIL-1 beta, while IL-2R beta did not appear on leukemic cells from any of the cases tested. IL-2R alpha-inducible pre-B ALL cases displayed stem cell antigen CD34 and induced myeloid-associated antigen CD13 simultaneously. These results suggest that IL-2R alpha but not IL-2R beta is easily inducible in certain cases of mature B-cell lymphoid neoplasm and pre-B ALL with immature characteristics.

• Authors: K Nakase, K Kita, S Shirakawa, I Tanaka, M Tsudo
• Journal: Leukemia research (Leuk Res) Vol. 18 Issue 11 Pg. 855-9 (Nov 1994) ISSN: 0145-2126 [Print] England
• PMID: 7526079 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antigens, CD
• Antigens, CD34
• Receptors, Interleukin-2
• CD13 Antigens

Topics

• Adult
• Antigens, CD (metabolism)
• Antigens, CD34
• CD13 Antigens (metabolism)
• Cell Membrane (metabolism)
• Female
• Humans
• Immunophenotyping
• Leukemia, B-Cell (immunology, metabolism, pathology)
• Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (immunology, metabolism, pathology)
• Pregnancy
• Receptors, Interleukin-2 (metabolism)
• Tumor Cells, Cultured (metabolism)