Treatment of linear localized scleroderma with the anti-allergic drug, tranilast.

Abstract	A 14-year-old boy with linear localized scleroderma had a dramatic improvement in contractures after treatment with N-(3',4'-dimethoxycinnamoyl) anthranilic acid (tranilast, Rizaben). The observation that this anti-allergic drug was effective in localized scleroderma lends further support to the concept that mast cells play a role in increased collagen synthesis in this disease.
Authors	S Taniguchi, T Yorifuji, T Hamada
Journal	Clinical and experimental dermatology (Clin Exp Dermatol) Vol. 19 Issue 5 Pg. 391-3 (Sep 1994) ISSN: 0307-6938 [Print] England
PMID	7525127 (Publication Type: Case Reports, Journal Article)
Chemical References	Histamine H1 Antagonists ortho-Aminobenzoates tranilast
Topics	Adolescent Histamine H1 Antagonists (therapeutic use) Humans Leg Male Movement Scleroderma, Localized (drug therapy, pathology, physiopathology) Toe Joint (physiopathology) ortho-Aminobenzoates (therapeutic use)

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