B-cell prolymphocytic leukemia expressing CD13 antigen.

Abstract

Although the expression of myeloid-associated antigen CD13 has been reported in aggressive B-cell chronic lymphocytic leukemia, its expression in other mature B-cell neoplasms appears to be rare. We report a 74-year-old female with B-cell prolymphocytic leukemia (B-PLL) expressing CD13 antigen. On admission, splenomegaly was noted. Hematological examination revealed a platelet count of 90 x 10(9)/l and a white cell count of 68 x 10(9)/l with 73% PLL cells. The hemoglobin concentration was 10.6 g/dl. A bone marrow aspirate showed a normocellular marrow with 64% PLL cells. Surface marker analysis of the PLL cells was positive for CD11b, CD13, CD19, CD20, CD24, HLA-DR, FMC7, mu and lambda. Simultaneous expression of CD13 and CD19 antigen was confirmed by dual color flow cytometry. Southern blot analysis of DNA from circulating mononuclear cells gave a rearranged band for the immunoglobulin gene (JH) but not for TCR-beta. Cytogenetic analysis of marrow cells showed an abnormal karyotype involving numbers 1, 7, 10, 12, 14, 15 chromosomes.

• Authors: A Matsushita, K Nagai, T Ishikawa, E Tatsumi, Y Ohno, T Takahashi
• Journal: International journal of hematology (Int J Hematol) Vol. 60 Issue 2 Pg. 157-61 (Aug 1994) ISSN: 0925-5710 [Print] Japan
• PMID: 7524729 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antigens, CD
• Antigens, CD19
• Antigens, Differentiation, B-Lymphocyte
• CD13 Antigens

Topics

• Aged
• Antigens, CD (metabolism)
• Antigens, CD19
• Antigens, Differentiation, B-Lymphocyte (metabolism)
• CD13 Antigens (metabolism)
• Female
• Flow Cytometry
• Humans
• Immunophenotyping
• Leukemia, B-Cell (immunology)
• Leukemia, Prolymphocytic (immunology)