Are rogue cells an indicator of cancer risk due to the action of bacterial restriction endonucleases?

Abstract

Cytogenetic surveys in normal individuals have occasionally shown the occurrence of cells with multiple chromosome-type aberrations in some of the subjects. These cells, which are rare, have been termed as rogue cells. Rogue cells, which have been observed worldwide, have a mysterious nature. It has been suggested that they may give rise to cancer. Various mechanisms have been considered for the causation of the rouge-cell phenomenon in the past but none of them appears to be fully justified. In this paper we propose their occurrence due to the action of bacterial restriction endonucleases.

• Authors: Y R Ahuja, G Obe
• Journal: Mutation research (Mutat Res) Vol. 310 Issue 1 Pg. 103-12 (Oct 01 1994) ISSN: 0027-5107 [Print] Netherlands
• PMID: 7523873 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• DNA Restriction Enzymes

Topics

• Animals
• Bacteria (enzymology)
• Bacterial Infections (enzymology, genetics)
• Chromosome Aberrations
• DNA Restriction Enzymes (metabolism)
• Humans
• Karyotyping
• Neoplasms (etiology, genetics, pathology)
• Precancerous Conditions (metabolism)
• Risk Factors