Efficacy of the hematoregulatory peptide SK&F 107647 in experimental systemic Candida albicans infections in normal and immunosuppressed mice.

Abstract

SK&F 107647, a novel synthetic dimeric pentapeptide, has been shown to be a potent hematoregulatory agent. The potential for the hematoregulatory factors elicited by SK&F 107647 to confer protection in experimental models of systemic Candida albicans infection was evaluated in immunosuppressed and immunocompetent mice. Prophylactic treatment with recombinant human interleukin-1 (rhIL-1), recombinant human granulocyte colony stimulating factor (rhG-CSF), or the hematoregulatory peptide SK&F 107647 significantly increased survival times in gamma irradiated immunosuppressed as well as non-irradiated immunocompetent mice challenged with a lethal dose of C. albicans. Protection was also observed in athymic nu/nu "nude" mice. Additionally, significant increases in survival in non-irradiated immunocompetent mice dosed by oral gavage were observed. These results indicate that SK&F 107647 can significantly enhance natural host resistance to experimental C. albicans infections both in immunosuppressed and immunocompetent mice.

• Authors: P L DeMarsh, S K Sucoloski, C L Frey, P K Bhatnagar, Y Koltin, P Actor, S R Petteway
• Journal: Immunopharmacology (Immunopharmacology) 1994 May-Jun Vol. 27 Issue 3 Pg. 199-206 ISSN: 0162-3109 [Print] Netherlands
• PMID: 7520890 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Interleukin-1
• Oligopeptides
• Recombinant Proteins
• Granulocyte Colony-Stimulating Factor
• SK&F 107647

Topics

• Animals
• Candidiasis (immunology, prevention & control)
• Disease Models, Animal
• Gamma Rays (adverse effects)
• Granulocyte Colony-Stimulating Factor (therapeutic use)
• Humans
• Immunosuppression Therapy
• Interleukin-1 (therapeutic use)
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Oligopeptides (therapeutic use)
• Recombinant Proteins (therapeutic use)
• Survival Rate