| Abstract | This study documents the reactions of the monoclonal antibody KP-1, which detects histiocytes in paraffin sections, with 137 sarcomas, 48 lymphomas, 28 carcinomas, 7 malignant melanomas and 8 cystosarcoma phyllodes. The soft tissue sarcomas had been previously immunophenotyped. Positive staining was obtained in all categories of sarcoma except clear-cell sarcomas. Most categories of sarcoma showed staining in less than 10% of tumour cells although a minority of leiomyosarcomas showed more extensive staining. Five of 7 malignant melanomas were also positive while all lymphomas and carcinomas were negative. We conclude that KP-1 positivity is not helpful in supporting the histiocytic origin of a tumour and is of limited value in the differential diagnosis of soft tissue sarcomas or their separation from other categories of malignancy. |
| Authors | M Cassidy, B Loftus, A Whelan, B Sabt, D Hickey, K Henry, M Leader
(Affiliation: Department of Pathology, Royal College of Surgeons in Ireland, Dublin.)
|
| Journal | Virchows Archiv : an international journal of pathology
(Virchows Arch)
Vol. 424
Issue 6
Pg. 635-40
( 1994)
ISSN: 0945-6317 GERMANY |
| PMID | 7519954
(Publication Type: Journal Article, Review)
|
| Chemical References |
- Antigens, CD
- Antigens, Differentiation, Myelomonocytic
- CD68 antigen, human
- Tumor Markers, Biological
|
| Topics |
- Antigens, CD
(analysis)
- Antigens, Differentiation, Myelomonocytic
(analysis)
- Breast Neoplasms
(chemistry)
- Carcinoma
(chemistry)
- Female
- Humans
- Lymphoma
(chemistry)
- Melanoma
(chemistry)
- Phyllodes Tumor
(chemistry)
- Sarcoma
(chemistry)
- Soft Tissue Neoplasms
(chemistry)
- Staining and Labeling
- Tumor Markers, Biological
(analysis)
|
