Abstract |
Susceptibility to pseudorabies virus (PRV) infection in mice, which were continuously depleted of natural killer (NK) cell activity by injection of anti- asialo GM1, was examined. Effects of serum thymic factor (FTS) on susceptibility of mice to PRV were also investigated. In mice with depleted NK cell activity, the mortality of PRV-infected mice was markedly high, whereas that of FTS-pretreated mice was significantly lower than the controls. Reduced susceptibility to PRV was demonstrated in mice treated with anti- asialo GM1 antisera before the PRV infection. Such a reduced susceptibility was not observed in mice inoculated with the antisera on day 1 post- infection (PI). To analyze the FTS-induced resistance to PRV infection, NK cell activity, macrophage activity, and interferon (IFN) productions were studied. Interferon production and NK cell activity were enhanced in the FTS-pretreated mice, suggesting that interferon may play an important role in this FTS-induced resistance to PRV infection.
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Authors | T Onodera, K Yoshihara, T Suzuki, T Tsuda, T Ikeda, A Awaya, H Kobayashi, M Yukawa |
Journal | Microbiology and immunology
(Microbiol Immunol)
Vol. 38
Issue 1
Pg. 47-53
( 1994)
ISSN: 0385-5600 [Print] Australia |
PMID | 7519717
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immune Sera
- G(M1) Ganglioside
- asialo GM1 ganglioside
- Interferons
- Thymic Factor, Circulating
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Topics |
- Amino Acid Sequence
- Animals
- Disease Susceptibility
(immunology)
- G(M1) Ganglioside
(antagonists & inhibitors, immunology)
- Herpesvirus 1, Suid
(immunology, pathogenicity, physiology)
- Immune Sera
- Immunity, Innate
- Interferons
(biosynthesis)
- Killer Cells, Natural
(drug effects, immunology)
- Macrophage Activation
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Pseudorabies
(immunology)
- Specific Pathogen-Free Organisms
- Thymic Factor, Circulating
(pharmacology, therapeutic use)
- Virulence
- Virus Replication
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