Abstract |
The initial cytogenetic analysis of a biphasic synovial sarcoma revealed complex anomalies involving six different chromosomes: 46,Y,t(X;18;5;4)(p11;q11;p13;q12),t(2;5)(q35;q11). After fluorescence in situ hybridization (FISH) analysis, using chromosome X-specific plasmid library and YAC probes, the situation appeared to be even more complex, with an insertion of part of the X chromosome short arm into the der(5)t(5;18). In spite of these complex chromosomal rearrangements, the Xp11 breakpoint could be mapped to within the ornithine aminotransferase (OAT)L1 cluster, very similar to that reported previously for the standard t(X;18)(p11;q11) in synovial sarcomas. These findings suggest common pathogenetic pathways in these cytogenetically different but morphologically similar tumors.
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Authors | D Olde Weghuis, M E Stoepker, B de Leeuw, E van den Berg, R F Suijkerbuijk, W M Molenaar, B de Jong, A Geurts van Kessel |
Journal | Genes, chromosomes & cancer
(Genes Chromosomes Cancer)
Vol. 9
Issue 4
Pg. 288-91
(Apr 1994)
ISSN: 1045-2257 [Print] United States |
PMID | 7519051
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Ornithine-Oxo-Acid Transaminase
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Topics |
- Adult
- Chromosomes, Human, Pair 18
(ultrastructure)
- Chromosomes, Human, Pair 2
(ultrastructure)
- Chromosomes, Human, Pair 4
(ultrastructure)
- Chromosomes, Human, Pair 5
(ultrastructure)
- Humans
- In Situ Hybridization, Fluorescence
- Male
- Ornithine-Oxo-Acid Transaminase
(genetics)
- Sarcoma, Synovial
(genetics)
- Soft Tissue Neoplasms
(genetics)
- Tendons
- Thigh
- Translocation, Genetic
- X Chromosome
(ultrastructure)
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