Abstract | OBJECTIVE: DESIGN: INTERVENTIONS: PATIENTS: MEASUREMENTS: RESULTS: Within 4 weeks of androgen administration to the seven patients without thyroid disease, serum levels of total T4 and T4-binding globulin decreased (P < 0.001), whereas the calculated free thyroxine index and measured free hormone levels remained unchanged. Six to 12 weeks after androgen therapy was discontinued, all seven patients remained clinically euthyroid, and serum levels returned to baseline values. In contrast, clinical hyperthyroidism developed shortly after androgen was administered to four patients who received long-term thyroid hormone replacement therapy. Within 4 weeks of treatment, the serum free T4 level increased in each of the four patients, whereas the TSH level decreased. Thyroid hormone doses had to be reduced by 25% to 50% to maintain euthyroidism. CONCLUSIONS:
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Authors | B M Arafah |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 121
Issue 4
Pg. 247-51
(Aug 15 1994)
ISSN: 0003-4819 [Print] United States |
PMID | 7518657
(Publication Type: Journal Article)
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Chemical References |
- Thyroxine-Binding Proteins
- Thyrotropin
- Fluoxymesterone
- Thyroxine
|
Topics |
- Aged
- Breast Neoplasms
(blood, complications, drug therapy)
- Female
- Fluoxymesterone
(pharmacology, therapeutic use)
- Humans
- Hypothyroidism
(blood, complications, drug therapy)
- Middle Aged
- Palliative Care
- Thyrotropin
(drug effects)
- Thyroxine
(administration & dosage, blood, drug effects, therapeutic use)
- Thyroxine-Binding Proteins
(drug effects)
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