Abstract |
This study evaluated changes in parathyroid hypertensive factor (PHF) in 18 obese individuals. PHF levels were measured prior to the onset of a low calorie diet (800 kcal/day), and at 3-4 weeks, 7-8 weeks, and 11-12 weeks after initiation of the diet. Blood pressure, forearm vascular resistance, and platelet intracellular calcium ([Ca2+]i) levels were also measured at the same time. Although blood pressure, vascular resistance, and platelet [Ca2+]i decreased significantly in association with the low-calorie diet and weight reduction, PHF levels did not change significantly during the 12-week diet period. We conclude that PHF levels do not track with reductions in blood pressure, vascular resistance, and platelet [Ca2+]i levels in obese individuals.
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Authors | J R Sowers, P R Standley, R Z Lewanczuk, P K Pang |
Journal | Journal of cardiovascular pharmacology
(J Cardiovasc Pharmacol)
Vol. 23 Suppl 2
Pg. S35-7
( 1994)
ISSN: 0160-2446 [Print] United States |
PMID | 7518544
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Biological Factors
- parathyroid hypertensive factor
- Calcium
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Topics |
- Animals
- Biological Factors
(blood)
- Blood Platelets
(metabolism)
- Blood Pressure
(physiology)
- Calcium
(blood)
- Diet, Reducing
- Female
- Humans
- Male
- Obesity
(blood, diet therapy)
- Rats
- Rats, Sprague-Dawley
- Vascular Resistance
(physiology)
- Weight Loss
(physiology)
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