Abstract | BACKGROUND/AIMS: METHODS: Rats were surgically prepared with electrodes implanted on the proximal colon and the abdominal striated muscles. Catheters were implanted in lateral ventricles of the brain. Rectal distension was performed by inflation of a balloon (0.1-1.6 mL) rectally inserted. CP-96,345 and RP-67,580 (neurokinin [NK] 1 antagonists) and SR-48,968 (NK2 antagonist) were injected intraperitoneally (IP) or intracerebroventricularly (ICV) 20 minutes before distension. GR-73,632 and GR-64,639 (NK1, NK2 agonists) were infused intravenously at 0.15 micrograms.kg-1.min-1. RESULTS: Rectal distension evoked a significant inhibition of colonic motility and an increase in abdominal contractions. CP-96,345 injected ICV (0.2-0.8 mg/kg) or IP (5-10 mg/kg) and RP-67,580 (0.2 mg/kg IP) eliminated distension-induced colonic inhibition but did not affect abdominal response. SR-48,968 did not affect colonic response but significantly reduced visceral pain (0.4, 0.8 mg/kg ICV: 5-10 mg/kg IP). GR-73,632 enhanced the rectal distension-induced colonic inhibition, whereas GR-64,349 induced a greater abdominal response. CONCLUSIONS: NK1 receptors mediate the rectocolonic inhibitory reflex, whereas NK2 receptors participate in visceral pain; both responses involve central structures.
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Authors | V Julia, O Morteau, L Buéno |
Journal | Gastroenterology
(Gastroenterology)
Vol. 107
Issue 1
Pg. 94-102
(Jul 1994)
ISSN: 0016-5085 [Print] United States |
PMID | 7517374
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Benzamides
- Biphenyl Compounds
- Hypnotics and Sedatives
- Indoles
- Isoindoles
- Peptide Fragments
- Piperidines
- Receptors, Neurokinin-1
- Receptors, Neurokinin-2
- Receptors, Tachykinin
- Tachykinins
- GR 73632
- 7,7-diphenyl-2-(1-imino-2-(2-methoxyphenyl)ethyl)perhydroisoindol-4-one
- neurokinin A (3-10), lysyl(3)-glycyl(8)-R-lactam-leucine(9)-
- Substance P
- SR 48968
- Neurokinin A
- CP 96345
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Topics |
- Abdomen
(physiology)
- Animals
- Benzamides
(pharmacology)
- Biphenyl Compounds
(pharmacology)
- Colon
(physiology)
- Colonic Diseases, Functional
(metabolism, pathology, physiopathology)
- Gastrointestinal Motility
(physiology)
- Hypnotics and Sedatives
(pharmacology)
- Indoles
(pharmacology)
- Isoindoles
- Male
- Neurokinin A
(analogs & derivatives, antagonists & inhibitors, pharmacology)
- Peptide Fragments
(pharmacology)
- Piperidines
(pharmacology)
- Rats
- Rats, Wistar
- Receptors, Neurokinin-1
(analysis, physiology)
- Receptors, Neurokinin-2
(analysis, physiology)
- Receptors, Tachykinin
(analysis, physiology)
- Rectum
(chemistry, pathology, ultrastructure)
- Substance P
(analogs & derivatives, antagonists & inhibitors, pharmacology)
- Tachykinins
(physiology)
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