Radioprotective effect of stobadine in the mouse micronucleus test.

Abstract

Induction of micronuclei was studied 40 h post irradiation in peripheral blood reticulocytes of male mice treated or not with stobadine dipalmitate (70.07 mg/kg body weight) at two time intervals (2 h or 1 h) prior to and immediately after 6.5 Gy 60Co exposure. A significant decrease of micronucleated reticulocytes was observed in the group of mice pretreated 2 h (P < 0.05) or 1 h (P < 0.01) before irradiation. 60Co irradiation followed by treatment with stobadine did not lead to the same protective effect in the micronucleus assay. It is therefore assumed that a radical-scavenging mechanism must be involved in radioprotection by stobadine.

• Authors: D Chorvatovicová
• Journal: Mutation research (Mutat Res) Vol. 324 Issue 1-2 Pg. 7-11 (Jun 1994) ISSN: 0027-5107 [Print] Netherlands
• PMID: 7515474 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Carbolines
• Cobalt Radioisotopes
• Radiation-Protective Agents
• dicarbine

Topics

• Animals
• Antioxidants (pharmacology)
• Carbolines (pharmacology)
• Cobalt Radioisotopes (toxicity)
• Male
• Mice
• Mice, Inbred ICR
• Micronucleus Tests
• Mutagenesis (drug effects)
• Radiation-Protective Agents
• Reticulocytes (radiation effects)