[Clinical experiences of granulocyte colony stimulating factor for granulocytopenia after AC bypass].

Abstract

We have successfully treated 3 cases of granulocytopenia, using Granulocyte Colony Stimulating Factor (G-CSF) after AC bypass surgery. All cases were male, aged 68, 75 & 54 years old, and underwent AC bypass surgery without transfusion except in case 1. Granulocyte cell counts decreased to 135/mm3 on 39th post-operative days (POD) in case 1, 624/mm3 on 13 rd POD in case 2, and 514/mm3 on 20th POD in case 3. In case 1, 300 micrograms of G-CSF was given intravenously for 3 days. In case 2, 100 micrograms of G-CSF for 1 day and 50 micrograms for 3 days was given subcutaneously, and in case 3, 100 micrograms of G-CSF was also given subcutaneously for 2 days. And their granulocyte cell counts all increased within few days. G-CSF is effective for patients with granulocytopenia after AC bypass surgery, but we need more experiences to know the best way of administration.

• Authors: M Yamamura, K Aoki, T Asakura, M Tadokoro, S Furuta, H Kashiwagi, H Itoh, K Sagara, S Abe, H Asakawa
• Journal: Kyobu geka. The Japanese journal of thoracic surgery (Kyobu Geka) Vol. 47 Issue 5 Pg. 364-7 (May 1994) ISSN: 0021-5252 [Print] Japan
• PMID: 7515127 (Publication Type: Case Reports, English Abstract, Journal Article, Review)

Chemical References

• Granulocyte Colony-Stimulating Factor

Topics

• Aged
• Agranulocytosis (therapy)
• Angina Pectoris (surgery)
• Coronary Artery Bypass
• Granulocyte Colony-Stimulating Factor (administration & dosage, therapeutic use)
• Humans
• Male
• Middle Aged
• Postoperative Complications (therapy)