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[A study of biological characteristics of large bowel adenocarcinomas showing mucin production; examination of histological differentiation and cell kinetics].

Abstract
In order to clarify the biological behavior of mucin producing cancers of colon, we analyzed 32 cases showing histological heterogeneity in the tumors, by mucin histochemistry. 28 cases were mucinous adenocarcinoma, forming with tubular structures, and the remaining 4 cases were signet-ring cell carcinomas. HID-AB stain demonstrated that the mucin component was almost similar to that of normal mucosa around the cancer. In the tubular forming portions, in which polyploid or aneuploid cells were often detected, the growth fraction of cancers was significantly higher than in that of the other portions.
AuthorsC Kawasaki, Y Hosokawa, T Hattori, M Suwo, M Hirano, A Yamamoto, M Fujimura, A Mori
JournalNihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology (Nihon Shokakibyo Gakkai Zasshi) Vol. 91 Issue 5 Pg. 976-87 (May 1994) ISSN: 0446-6586 [Print] Japan
PMID7515123 (Publication Type: English Abstract, Journal Article)
Chemical References
  • DNA, Neoplasm
  • Mucins
  • Nuclear Proteins
  • Proliferating Cell Nuclear Antigen
Topics
  • Adenocarcinoma, Mucinous (metabolism, mortality, pathology)
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Signet Ring Cell (metabolism, mortality, pathology)
  • Cell Cycle
  • Colonic Neoplasms (metabolism, mortality, pathology)
  • DNA, Neoplasm (analysis)
  • Female
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Mucins (biosynthesis)
  • Nuclear Proteins
  • Proliferating Cell Nuclear Antigen
  • Staining and Labeling
  • Survival Rate

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