Abstract |
Accumulating evidence suggests that c-kit plays an important role in the regulation of growth of at least 3 lineages of stem cells, while only very limited data are available on the development of human solid tumors. Our recent studies have shown that c-kit transcripts are expressed in a very restricted sub-set of human solid tumors such as small-cell lung cancer (SCLC). We have also conducted an immunohistological study on in situ localization of the c-kit protein in various human solid tumors as well as in corresponding fetal and adult normal tissues. No c-kit expression was detected in normal bronchial epithelial cells or pneumocytes in lung parenchyma of human fetal and adult specimens, indicating that the c-kit protein is aberrantly expressed in lung-cancer cells. We also found that significant chemotactic response as well as moderate in vitro cell growth occurred in SCLC cell lines upon addition of recombinant human stem-cell factor.
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Authors | T Hida, R Ueda, Y Sekido, K Hibi, R Matsuda, Y Ariyoshi, T Sugiura, T Takahashi, T Takahashi |
Journal | International journal of cancer. Supplement = Journal international du cancer. Supplement
(Int J Cancer Suppl)
Vol. 8
Pg. 108-9
( 1994)
ISSN: 0898-6924 [Print] United States |
PMID | 7515024
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hematopoietic Cell Growth Factors
- Proto-Oncogene Proteins
- RNA, Messenger
- Receptors, Colony-Stimulating Factor
- Recombinant Proteins
- Stem Cell Factor
- Proto-Oncogene Proteins c-kit
- Receptor Protein-Tyrosine Kinases
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Topics |
- Adenocarcinoma
(genetics, metabolism, pathology)
- Adult
- Carcinoma, Non-Small-Cell Lung
(genetics, metabolism, pathology)
- Carcinoma, Squamous Cell
(genetics, metabolism, pathology)
- Cell Division
(drug effects)
- Cell Line
- Chemotaxis
(drug effects)
- Fetus
- Gene Expression
- Hematopoietic Cell Growth Factors
(biosynthesis, pharmacology)
- Humans
- Lung Neoplasms
(genetics, metabolism, pathology)
- Proto-Oncogene Proteins
(analysis, biosynthesis, genetics)
- Proto-Oncogene Proteins c-kit
- Proto-Oncogenes
- RNA, Messenger
(biosynthesis)
- Receptor Protein-Tyrosine Kinases
(analysis, biosynthesis, genetics)
- Receptors, Colony-Stimulating Factor
(analysis, biosynthesis, genetics)
- Recombinant Proteins
(pharmacology)
- Reference Values
- Stem Cell Factor
- Tumor Cells, Cultured
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