Abstract |
The mechanisms of extramedullary leukemic infiltration are not well characterized. The cell-surface glycoprotein CD56, which is identical to the neural cell adhesion molecule, may be involved. Using the Leu-19 antibody and flow cytometric methods, the leukemic blasts of 22% (70 of 314) of patients were CD56 positive. This was most common in acute monocytic leukemia (15 of 18, 83%) and in patients with the cytogenetic abnormalities t(8;21) (seven of 13, 54%) and trisomy 8 (nine of 22, 41%). CD56 expression was not associated with extramedullary leukemic infiltration, but was correlated with positivity for CD11b (p < 0.001), CD14 (p < 0.001) and CD19 (p = 0.018). Although associated with morphologic and cytogenetic features, CD56 expression alone cannot account for most instances of tissue infiltration in acute myeloid leukemia (AML).
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Authors | J F Seymour, S A Pierce, H M Kantarjian, M J Keating, E H Estey |
Journal | Leukemia
(Leukemia)
Vol. 8
Issue 5
Pg. 823-6
(May 1994)
ISSN: 0887-6924 [Print] England |
PMID | 7514247
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD
- Antigens, CD19
- Antigens, Differentiation, B-Lymphocyte
- Antigens, Differentiation, Myelomonocytic
- Antigens, Differentiation, T-Lymphocyte
- CD56 Antigen
- Cell Adhesion Molecules, Neuronal
- Lipopolysaccharide Receptors
- Macrophage-1 Antigen
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Animals
- Antigens, CD
(analysis)
- Antigens, CD19
- Antigens, Differentiation, B-Lymphocyte
(analysis)
- Antigens, Differentiation, Myelomonocytic
(analysis)
- Antigens, Differentiation, T-Lymphocyte
(analysis)
- CD56 Antigen
- Cats
- Cell Adhesion Molecules, Neuronal
(analysis)
- Chromosome Aberrations
- Chromosomes, Human, Pair 21
- Chromosomes, Human, Pair 8
- Female
- Flow Cytometry
- Humans
- Immunophenotyping
- Karyotyping
- Leukemia, Monocytic, Acute
(immunology)
- Leukemia, Myeloid, Acute
(genetics, immunology, pathology)
- Leukemic Infiltration
- Lipopolysaccharide Receptors
- Macrophage-1 Antigen
(analysis)
- Male
- Translocation, Genetic
- Trisomy
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