Abstract |
Six patients with acute myeloid leukemia (AML) expressing CD7 antigen (CD7+ AML) were studied. They consisted of five patients with M1 and one with an M2 morphology. Two cases expressed other lymphoid-associated antigens, in addition to CD7. The complete remission rate was 50%. One patient had central nervous system recurrence. Cytogenetic analysis demonstrated normal karyotypes in all the cases. All but one had germline configurations of the T-cell receptor (TCR) genes and immunoglobulin heavy chain gene. However, all did not have detectable recombinase activating gene-1 activity by the RT-PCR technique. We performed colony formation assay in two patients, and no enhancement of colony formation by granulocyte colony-stimulating factor was noted. The results presented here, together with those reported previously, suggest that CD7+ AML may demonstrate lineage infidelity.
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Authors | T Shimamoto, J H Ohyashiki, K Ohyashiki, K Kawakubo, Y Inatomi, H Fujieda, S Nakazawa, N Kimura, J Miyauchi, K Toyama |
Journal | Cancer genetics and cytogenetics
(Cancer Genet Cytogenet)
Vol. 73
Issue 1
Pg. 69-74
(Mar 1994)
ISSN: 0165-4608 [Print] United States |
PMID | 7513604
(Publication Type: Journal Article, Review)
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Chemical References |
- Antigens, CD
- Antigens, CD7
- Antigens, Differentiation, T-Lymphocyte
- DNA Primers
- Homeodomain Proteins
- Immunoglobulin Heavy Chains
- Immunoglobulin Joining Region
- Receptors, Antigen, T-Cell
- RAG-1 protein
- Granulocyte Colony-Stimulating Factor
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Topics |
- Adult
- Antigens, CD
(analysis)
- Antigens, CD7
- Antigens, Differentiation, T-Lymphocyte
(analysis)
- Base Sequence
- Child
- DNA Primers
- Female
- Granulocyte Colony-Stimulating Factor
(pharmacology)
- Homeodomain Proteins
- Humans
- Immunoglobulin Heavy Chains
(genetics)
- Immunoglobulin Joining Region
(genetics)
- Immunophenotyping
- Karyotyping
- Leukemia, Myeloid, Acute
(genetics, immunology, physiopathology)
- Male
- Middle Aged
- Molecular Sequence Data
- Protein Biosynthesis
- Receptors, Antigen, T-Cell
(genetics)
- Tumor Cells, Cultured
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