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Clinical and biologic characteristics of CD7+ acute myeloid leukemia. Our experience and literature review.

Abstract
Six patients with acute myeloid leukemia (AML) expressing CD7 antigen (CD7+ AML) were studied. They consisted of five patients with M1 and one with an M2 morphology. Two cases expressed other lymphoid-associated antigens, in addition to CD7. The complete remission rate was 50%. One patient had central nervous system recurrence. Cytogenetic analysis demonstrated normal karyotypes in all the cases. All but one had germline configurations of the T-cell receptor (TCR) genes and immunoglobulin heavy chain gene. However, all did not have detectable recombinase activating gene-1 activity by the RT-PCR technique. We performed colony formation assay in two patients, and no enhancement of colony formation by granulocyte colony-stimulating factor was noted. The results presented here, together with those reported previously, suggest that CD7+ AML may demonstrate lineage infidelity.
AuthorsT Shimamoto, J H Ohyashiki, K Ohyashiki, K Kawakubo, Y Inatomi, H Fujieda, S Nakazawa, N Kimura, J Miyauchi, K Toyama
JournalCancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 73 Issue 1 Pg. 69-74 (Mar 1994) ISSN: 0165-4608 [Print] United States
PMID7513604 (Publication Type: Journal Article, Review)
Chemical References
  • Antigens, CD
  • Antigens, CD7
  • Antigens, Differentiation, T-Lymphocyte
  • DNA Primers
  • Homeodomain Proteins
  • Immunoglobulin Heavy Chains
  • Immunoglobulin Joining Region
  • Receptors, Antigen, T-Cell
  • RAG-1 protein
  • Granulocyte Colony-Stimulating Factor
Topics
  • Adult
  • Antigens, CD (analysis)
  • Antigens, CD7
  • Antigens, Differentiation, T-Lymphocyte (analysis)
  • Base Sequence
  • Child
  • DNA Primers
  • Female
  • Granulocyte Colony-Stimulating Factor (pharmacology)
  • Homeodomain Proteins
  • Humans
  • Immunoglobulin Heavy Chains (genetics)
  • Immunoglobulin Joining Region (genetics)
  • Immunophenotyping
  • Karyotyping
  • Leukemia, Myeloid, Acute (genetics, immunology, physiopathology)
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Protein Biosynthesis
  • Receptors, Antigen, T-Cell (genetics)
  • Tumor Cells, Cultured

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