The endothelin ETA receptor antagonist, BQ-123, normalizes the response of SHR aorta to Ca2+ channel activator.

Abstract

Hypertension is associated with a hypersensitive response to the Ca2+ channel activator, Bay K 8644. We investigated the effect of the endothelin ETA receptor antagonist, BQ-123, on the contractions induced by Bay K 8644 in aorta from spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats. BQ-123 (1 microM) decreased the sensitivity to Bay K 8644 of aorta of SHR down to that of WKY. This observation is consistent with a role for endothelin in hypertension.

• Authors: N Morel, T Godfraind
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 252 Issue 2 Pg. R3-4 (Feb 03 1994) ISSN: 0014-2999 [Print] Netherlands
• PMID: 7512502 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium Channel Agonists
• Calcium Channel Blockers
• Endothelin Receptor Antagonists
• Peptides, Cyclic
• 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
• cyclo(Trp-Asp-Pro-Val-Leu)

Topics

• 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester (antagonists & inhibitors, pharmacology)
• Animals
• Aorta, Thoracic (drug effects)
• Blood Pressure (drug effects)
• Calcium Channel Agonists (pharmacology)
• Calcium Channel Blockers
• Endothelin Receptor Antagonists
• In Vitro Techniques
• Isometric Contraction (drug effects)
• Muscle, Smooth, Vascular (drug effects)
• Peptides, Cyclic (pharmacology)
• Rats
• Rats, Inbred SHR
• Rats, Inbred WKY