Abstract | OBJECTIVE: DESIGN: An uncontrolled observational study. SETTING: A public family planning center in Paris. PATIENTS: INTERVENTIONS: Six hundred milligrams (600 mg) of oral mifepristone followed 48 hours later by an IM injection of 250 micrograms of sulprostone. MAIN OUTCOME MEASURES: RESULTS: There was complete abortion in 93.2% of the cases. Of the 25 failures, 8 were continued pregnancies, 6 terminated pregnancy but without expulsion of the conceptus, and 11 were placenta retentions. Eight women required short hospitalization, but none needed blood transfusion. Among the 25 failures, 23 had a beta-hCG concentration > 500 IU/mL [sensitivity 92%, specificity 83%]. CONCLUSION: The sequential use of oral mifepristone and IM injection of sulprostone is effective in inducing abortion up to 7 weeks of amenorrhea. Nevertheless the risk of maternal morbidity associated with sulprostone and also the risk of fetal malformations in cases of continued pregnancy indicate that this method should only be used in specialist centers.
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Authors | P Thonneau, B Fougeyrollas, A Spira |
Journal | Fertility and sterility
(Fertil Steril)
Vol. 61
Issue 4
Pg. 627-31
(Apr 1994)
ISSN: 0015-0282 [Print] United States |
PMID | 7512053
(Publication Type: Journal Article)
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Chemical References |
- Chorionic Gonadotropin
- Chorionic Gonadotropin, beta Subunit, Human
- Peptide Fragments
- Mifepristone
- sulprostone
- Dinoprostone
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Topics |
- Abortion, Induced
- Adult
- Chorionic Gonadotropin
(blood)
- Chorionic Gonadotropin, beta Subunit, Human
- Dinoprostone
(administration & dosage, analogs & derivatives)
- Female
- France
- Humans
- Mifepristone
(administration & dosage)
- Peptide Fragments
(blood)
- Pregnancy
- Regression Analysis
- Retrospective Studies
- Time Factors
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