Isotype and antigen specificity of pertussis agglutinins following whole-cell pertussis vaccination and infection with Bordetella pertussis.

Abstract

Elevated agglutinin titers have been shown to correlate with protection from disease following whole-cell pertussis vaccination, but the isotype and antigen specificity of human agglutinating antibodies is unknown. In 13 immunoassays, immunoglobulin G antifimbria antibodies had the strongest correlation with agglutinin titers following culture-proven infection with Bordetella pertussis (R' = 0.79; P < 0.0001) and following whole-cell pertussis vaccination (R' = 0.87, P < 0.0001).

• Authors: C M Mink, C H O'Brien, S Wassilak, A Deforest, B D Meade
• Journal: Infection and immunity (Infect Immun) Vol. 62 Issue 3 Pg. 1118-20 (Mar 1994) ISSN: 0019-9567 [Print] United States
• PMID: 7509316 (Publication Type: Journal Article)

Chemical References

• Agglutinins
• Antibodies, Bacterial
• Epitopes
• Immunoglobulin Isotypes
• Pertussis Vaccine

Topics

• Agglutinins (analysis)
• Antibodies, Bacterial (analysis)
• Enzyme-Linked Immunosorbent Assay
• Epitopes
• Humans
• Immunoglobulin Isotypes (analysis)
• Pertussis Vaccine (immunology)
• Vaccination
• Whooping Cough (immunology)