In vivo cytogenetic analyses of the carbamate pesticides Dithane M-45 and Baygon in mice.

Abstract

Two carbamate pesticides, Dithane M-45 and Baygon, were analysed for their cytogenetic effects using meiotic chromosome analysis and the micronucleus test in Swiss albino male mice. The three sub-lethal doses of 1687.5, 3375 and 5962.5 mg/kg bw of Dithane M-45 and 1250, 2500 and 3750 mg/kg bw of Baygon were employed in all the experiments. The results demonstrate that neither Dithane M-45 nor Baygon could induce a significant (P > 0.05) increase in the number of chromosomal aberrations in the germ cells or in the percentage of micronuclei in erythrocytes.

• Authors: V Vasudev, N B Krishnamurthy
• Journal: Mutation research (Mutat Res) Vol. 323 Issue 3 Pg. 133-5 (Mar 1994) ISSN: 0027-5107 [Print] Netherlands
• PMID: 7509028 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Insecticides
• Maneb
• dithane M-45
• Propoxur
• Zineb

Topics

• Analysis of Variance
• Animals
• Chi-Square Distribution
• Chromosome Aberrations
• Insecticides (toxicity)
• Male
• Maneb (analogs & derivatives, toxicity)
• Meiosis (drug effects)
• Mice
• Micronucleus Tests
• Mitosis (drug effects)
• Propoxur (toxicity)
• Spermatogonia (drug effects)
• Zineb (analogs & derivatives, toxicity)