Immunostaining for Leu-7 in the diagnosis of thyroid carcinoma.

Abstract

The morphologic distinction between benign and malignant thyroid lesions can be difficult. Immunostaining for the Leu-7 antigen has been reported to be useful in the diagnosis of thyroid carcinoma. To test the specificity of immunostaining for Leu-7 in the diagnosis of thyroid carcinoma, we studied formalin-fixed, paraffin-embedded tissue specimens obtained from 66 thyroid lesions using the HNK-1 monoclonal antibody to Leu-7 and an avidin-biotin-complex technique. Positive reactivity for Leu-7 was seen in 11 (33%) of 33 benign thyroid conditions and in 27 (82%) of 33 thyroid carcinomas. We conclude that immunostaining for Leu-7 is not specific in the diagnosis of thyroid carcinoma.

• Authors: T S Loy, G V Darkow, L E Spollen, A A Diaz-Arias
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 118 Issue 2 Pg. 172-4 (Feb 1994) ISSN: 0003-9985 [Print] United States
• PMID: 7508715 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal
• Antigens, CD
• Antigens, Differentiation, T-Lymphocyte
• CD57 Antigens
• Avidin
• Biotin

Topics

• Antibodies, Monoclonal
• Antigens, CD (metabolism)
• Antigens, Differentiation, T-Lymphocyte (metabolism)
• Avidin
• Biotin
• CD57 Antigens
• Carcinoma (metabolism, pathology)
• Humans
• Immunologic Techniques
• Staining and Labeling
• Thyroid Neoplasms (metabolism, pathology)