Abstract |
The aim of the present work is to determine the radioprotective capacity of chlorophyllin, by measuring the reduction of gamma-ray-induced sister-chromatid exchange (SCE) in murine bone marrow cells in vivo. The results obtained in two separate experiments, using 10, 50 and 100 micrograms of chlorophyllin per g of body weight (bw), indicate that chlorophyllin per se did not have any effect on the SCE frequency and that the dose of 100 micrograms/g bw protects 100% against the induction of SCE by 1.0 Gy of gamma-rays; 50 micrograms/g bw protects less than 50% and 10 micrograms/g bw affords no protection.
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Authors | P Morales-Ramírez, M C García-Rodríguez |
Journal | Mutation research
(Mutat Res)
Vol. 320
Issue 4
Pg. 329-34
(Mar 1994)
ISSN: 0027-5107 [Print] Netherlands |
PMID | 7508558
(Publication Type: Journal Article)
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Chemical References |
- Antimutagenic Agents
- Chlorophyllides
- chlorophyllin
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Topics |
- Animals
- Antimutagenic Agents
(administration & dosage, pharmacology)
- Body Weight
- Bone Marrow
(radiation effects)
- Chlorophyllides
(administration & dosage, pharmacology)
- Male
- Mice
- Mice, Inbred BALB C
- Sister Chromatid Exchange
(drug effects)
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