Indapamide reduces hypertensive left ventricular hypertrophy: an international multicenter study.

Abstract

The effect of 6 months of treatment with indapamide (IND, 2.5 mg/day) on regression of left ventricular hypertrophy (LVH), an independent predictor of poor prognosis in hypertension, was compared by echocardiography to that of nifedipine (NFD, 40 mg/day), enalapril (ENL, 20 mg/day), atenolol (ATL, 100 mg/day), and hydrochlorothiazide (HCTZ, 25 mg/day) in four parallel double-blind studies in 151 hypertensive patients with a diastolic blood pressure between 95 and 120 mm Hg and a raised left ventricular mass index (LVMI) (mg/m2) (Devereux). Patients were randomized to IND or comparator following a 2-week washout (1 month in the IND vs. ATL study). Respective baseline and 6-month LVMI values (mg/m2) were: IND (n = 20) vs. HCTZ (n = 20): 151.4 +/- 6.3 and 125.70 +/- 4.6 (p < 0.001) vs. 141.3 +/- 6.6 and 135.6 +/- 8.3 (p = N.S.); IND (n = 22) vs NFD (n = 19): 144.1 +/- 5.3 and 125.1 +/- 4.3 (p < 0.001) vs. 170.4 +/- 6.6 and 148.2 +/- 6.2 (p < 0.001); IND (n = 9) vs. ENL (n = 9): 155.1 +/- 6.3 and 143.4 +/- 5.2 (p < 0.001) vs. 142.0 +/- 6.7 and 130.0 +/- 5.9 (p < 0.001); IND (n = 17) vs. ATL (n = 12): 146.2 +/- 5.1 and 130.8 +/- 6.5 (p < 0.001) vs. 156.7 +/- 8.4 and 142.9 +/- 10.3 (p < 0.01). All drugs significantly reduced diastolic blood pressure, and all except HCTZ induced a significant and similar reduction in left ventricular mass.

• Authors: R Senior, J L Imbs, M Bory, G Amabile, B Denis, F Zannad, N De Luca, R Marchegiano, A Lahiri, E B Raftery
• Journal: Journal of cardiovascular pharmacology (J Cardiovasc Pharmacol) Vol. 22 Suppl 6 Pg. S106-10 ( 1993) ISSN: 0160-2446 [Print] United States
• PMID: 7508055 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Hydrochlorothiazide
• Atenolol
• Enalapril
• Indapamide
• Nifedipine

Topics

• Adult
• Aged
• Atenolol (pharmacology, therapeutic use)
• Blood Pressure (drug effects)
• Double-Blind Method
• Enalapril (pharmacology, therapeutic use)
• Female
• France
• Humans
• Hydrochlorothiazide (pharmacology, therapeutic use)
• Hypertension (complications, drug therapy)
• Hypertrophy, Left Ventricular (drug therapy, etiology)
• Indapamide (pharmacology, therapeutic use)
• Italy
• Male
• Middle Aged
• Nifedipine (pharmacology, therapeutic use)
• United Kingdom