Double-blind evaluation of nimesulide vs lysine-aspirin in the treatment of paediatric acute respiratory tract infections.

Abstract

70 children aged 4 to 12 years with acute infection and inflammation of the respiratory tract (laryngitis, tracheitis, bronchitis, pneumonia) were enrolled in a double-blind investigation and randomised to treatment with nimesulide (50mg granules twice daily) or lysine-aspirin (360mg granules twice daily) for 5 days. The drugs were similarly effective in reducing cough, asthenia and dyspnoea, although nimesulide-treated patients experienced fewer gastrointestinal adverse events. These results confirm the efficacy of nimesulide in the treatment of respiratory inflammation and provide preliminary evidence of its value in children.

• Authors: I Barberi, A Macchia, N Spata, I Scaricabarozzi, M L Nava
• Journal: Drugs (Drugs) Vol. 46 Suppl 1 Pg. 219-21 ( 1993) ISSN: 0012-6667 [Print] New Zealand
• PMID: 7506176 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Sulfonamides
• Lysine
• Aspirin
• nimesulide
• acetylsalicylic acid lysinate

Topics

• Acute Disease
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Aspirin (analogs & derivatives, therapeutic use)
• Child
• Child, Preschool
• Double-Blind Method
• Female
• Humans
• Lysine (analogs & derivatives, therapeutic use)
• Male
• Respiratory Tract Infections (drug therapy)
• Sulfonamides (therapeutic use)