A double-blind study of the efficacy of nimesulide in the treatment of ankle sprain in comparison with placebo.

Abstract

In a randomised double-blind study, nimesulide 100mg twice daily for 8 days was compared with placebo in the treatment of 60 patients with ankle sprain. On day 4, three nimesulide-treated patients discontinued treatment because of resolution of their symptoms, whereas 11 patients in the placebo group discontinued as a result of worsening symptoms. A significantly greater reduction in pain, functional impairment and swelling was observed with nimesulide compared with placebo; moreover, the time to improvement was significantly shorter with the active treatment. The overall evaluation of efficacy favoured nimesulide over placebo (p < 0.001). Both medications were well tolerated, with 5 patients reporting mild gastralgia (4 treated with nimesulide and 1 with placebo), while 1 placebo-treated patient reported a mild gastrointestinal disturbance. These results suggest that nimesulide is an effective treatment for the short term management of post-traumatic pain states.

• Authors: R L Dreiser, D Riebenfeld
• Journal: Drugs (Drugs) Vol. 46 Suppl 1 Pg. 183-6 ( 1993) ISSN: 0012-6667 [Print] New Zealand
• PMID: 7506167 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Sulfonamides
• nimesulide

Topics

• Adolescent
• Adult
• Aged
• Ankle Injuries (drug therapy)
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Sprains and Strains (drug therapy)
• Sulfonamides (therapeutic use)