A series of extracted fractions from sophora subprostrata was screened by determining anti-
ulcer effects in pylorus ligated and stressed rats. Fr. [C-2] had the most potent anti-
ulcer effects of all fractions extracted. Sophoradin and
sophoranone which were isolated from Fr. [C-2] were also found to have inhibitory effects on
ulcer formation in pylorus ligated and stressed rats. The anti-
ulcer effect of sophoradin was relatively potent in comparison with that of
sophoranone and/or Fr. [C-2]. The anti-
ulcer effect of
sophoranone was approximately the same as that of Fr. [C-2]. The authors examined the effects of sophoradin and
sophoranone on gastric secretion in pylorus ligated rats. Sophoradin and
sophoranone significantly reduced the volume of gastric juice. Sophoradin but not
sophoranone inhibited the free and total
acid output of gastric juice. The effect of sophoradin was examined on various
secretagogues which induced gastric secretions in rats with acute
fistula. Sophoradin showed a tendency to inhibit
tetragastrin- and
insulin-induced gastric acid secretion, but there were no effects on
methacholine- and
histamine-induced secretions. These results suggest that sophoradin may have marked anti-
ulcer and inhibitory effects on gastric secretion.