HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Proteolytic proenzymes in the pancreas in the course of experimental bile-induced pancreatitis in the guinea pig.

Abstract
The levels of the proenzymes trypsinogen and chymotrypsinogen were studied in guinea pigs with pancreatitis induced by injection of sodium taurocholate containing the antibiotic cephalothin. This treatment inhibited the enzyme activities and prolonged the activation times of the proenzymes. Both trypsinogen and chymotrypsinogen content decreased after induction of pancreatitis, but there were no significant changes in the proenzyme contents in relation to injection-to-excision times. Sodium taurocholate and cephalothin were cleared from the pancreas in 2 h. Administration of chlorophyll-a together with the inducer caused a slight increase in proenzyme levels.
AuthorsD Harell, R Orda, T Wiznitzer, J B Bawnik, G Feinstein, M Sokolovsky
JournalDigestion (Digestion) Vol. 18 Issue 5-6 Pg. 394-401 ( 1978) ISSN: 0012-2823 [Print] Switzerland
PMID750263 (Publication Type: Journal Article)
Chemical References
  • Chlorophyll
  • Taurocholic Acid
  • Trypsinogen
  • Chymotrypsinogen
  • Esterases
  • Cephalothin
Topics
  • Animals
  • Cephalothin
  • Chlorophyll
  • Chymotrypsinogen (metabolism)
  • Esterases (metabolism)
  • Guinea Pigs
  • Pancreas (enzymology)
  • Pancreatitis (chemically induced, enzymology)
  • Taurocholic Acid
  • Trypsinogen (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: