Carcinogenicity of dietary dimethylnitrosomorpholine, N-methyl-N'-nitro-N-nitrosoguanidine, and dibromoethane in rainbow trout.

Abstract

Eighteen-mo feeding trials of rainbow trout were used to test the carcinogenicity of 5 chemicals in this species. A single exposure level was used for each substance. The doses and chemicals tested were 1,556 ppm 2,6-dimethylnitrosomorpholine (DMNM), 500 ppm N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), 2,000 ppm 1,2-dibromoethane (DBE), 2,000 ppm 1,1-dichloroethylene (DCE), and 200 ppm cyclophosphamide (CP). Liver and/or glandular stomach neoplasms were produced by DMNM (liver and stomach), MNNG (stomach), and DBE (chiefly, stomach tumors). In addition, DMNM produced a low incidence of swimbladder papillomas and caused testicular atrophy in 50% of treated males. DCE and CP produced no neoplasms at the exposure levels used. No evidence of other chronic toxicity was seen for any of the 5 compounds.

• Authors: J D Hendricks, D W Shelton, P M Loveland, C B Pereira, G S Bailey
• Journal: Toxicologic pathology (Toxicol Pathol) 1995 Jul-Aug Vol. 23 Issue 4 Pg. 447-57 ISSN: 0192-6233 [Print] United States
• PMID: 7501957 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Carcinogens
• Dichloroethylenes
• Nitrosamines
• Methylnitronitrosoguanidine
• N-nitroso-2,6-dimethylmorpholine
• Ethylene Dibromide
• vinylidene chloride
• Cyclophosphamide

Topics

• Animal Feed
• Animals
• Carcinogens
• Cyclophosphamide (toxicity)
• Dichloroethylenes (toxicity)
• Ethylene Dibromide (toxicity)
• Female
• Male
• Methylnitronitrosoguanidine (toxicity)
• Nitrosamines (toxicity)
• Oncorhynchus mykiss
• Sex Characteristics